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Federated-GWAS-Pipeline

Private, secure, and reproducible federated GWAS documentation for multi-center studies that need strong data ownership and auditable analysis.

Private by designSecure aggregationFederated analysis
Pipeline CapabilitiesPrivacy-first
Encrypted transport

Secure Channel

ECC key exchange and pairwise PRG masking for aggregate communication.

PLINK-backed QC

Quality Control

Local and global filtering for missingness, MAF, and HWE thresholds.

Multi-center GWAS

Federated Association Study

Distributed PLINK logistic regression with center-level data ownership.

Privacy by design

Strong Privacy Protection

No raw genotype centralization, deterministic anonymization, and masked statistics.

Built for research operations

The documentation follows the repository structure so researchers can move from setup to pipeline internals without switching mental models.

Federated GWAS workflow

Coordinate quality control, kinship analysis, local regression filtering, and final association analysis across multiple centers.

Privacy-aware aggregation

Use ECC key exchange, pairwise PRG masking, and deterministic ID anonymization to reduce raw data exposure during collaboration.

Experiment-ready layout

Run repeatable Flower simulation and local-deployment experiments with scenario-specific configs, logs, and result directories.